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KMID : 0377519750010010003
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Chung-Ang Journal of Medicine
1975 Volume.1 No. 1 p.3 ~ p.10
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Effects of Histamine on Fluid Volume Movement in the Intestinal Loop Preparation
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Song Tae-Ho
Kim Hyung-Keun
Uhm Dae-Yong
Rhee Sang-Don
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Abstract
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In vitro perfusion experiment was done to observe the effects of histamine on the transport of fluid from capillary into the intestinal lumen of rabbits weighing 2-2.8㎏. After performing the control perfusion with an artificial perfusate, histamine was added to the perfusing solution at a concentration of 1 ㎍/50ml perfusate and perfusion experiment was repeated. Mean capillary pressure (Pc), precapillary resistance(Ra), postcapillary resistance(Rv) and total tissue resistance (Rt) were calculated from the measured data of isogravimetric capillary pressure (Pci), arterial pressure (Pa), venous pressure (Pv), venous flow rate (Qv), luminal flow rate (Q_L) and weight of the intestinal loop. Decreased Pci from 19.5㎜ Hg of the control group to 15.2㎜ Hg of the histamine group had resulted from increased capillary permeability. And increased Pc was observed in the histamine group compared to the control due to the decrease in pre-to-postcapillary resistance ratio in the histamine perfused loop. Decreased Rt in the histamine group was also responsible in facilitating the fluid movement from capillary to intestinal lumen in addition to the effect of increased Pc. When Pc and Q_L were plotted linear relationships were observed and the slope of the histamine group was steeper than that of the control indicating increased volume movement "coefficient" in the histamine group.
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